Living Organisms
Cayman Chemical BIX01294hydrochLRIde hydra 5mg
A selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known histone methyltransferases
Cayman Chemical FrovatrIptnsuccInAT hydra 50mg
An agonist of 5-HT1B and 5-HT1D receptors (Kis = 2.51 and 3.98 nM, respectively); selective for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2C, 5-HT3, and 5-HT7 receptors, as well as dopamine D1, D2, and D3, histamine H1, and α1-adrenergic receptors (Kis = >50 nM); induces contractions in human basilar arteries isolated post-mortem, coronary arteries from transplant recipient hearts, and coronary arteries from donor hearts unsuitable for transplantation (EC50s = 13.8, 41.69, and 15.49 nM, respectively); increases carotid vascular resistance in closed-chest and open-chest anesthetized dogs (ED50s = 6 and 1 nmol/kg, i.v., respectively)
Cayman Chemical Clodronate sodium salt hydra
A non-nitrogenous bisphosphonate that inhibits hydroxyapatite crystal growth (IC50 = 1.34 µM) and bone resorption; is cytotoxic to both osteoclasts and macrophages and has been used in biological research to selectively induce apoptosis of macrophage-like cells and cancer cells
Cayman Chemical Harmalol hydrochloride hydra
A β-carboline alkaloid and an active metabolite of harmaline; an inhibitor of DYRK1A (IC50 = 0.63 µM); an inhibitor of MAO-A (IC50 = 0.66 µM); selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM; inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM); reduces TCDD-induced increases in CYP1A1 levels in HepG2 cells and prevents TCDD-induced activation of AhR in guinea pig hepatic cytosolic extracts; reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and ROS production in PC12 cells at 25 µM
Cayman Chemical BIX01294hydroCLOrID hydra 50mg
A selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known histone methyltransferases
Cayman Chemical DoxapramhydroCLOrID hydra 25mg
A central respiratory stimulant; increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg; acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation